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Alcohol and Alcoholism Advance Access originally published online on April 25, 2005
Alcohol and Alcoholism 2005 40(4):283-290; doi:10.1093/alcalc/agh162
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© The Author 2005. Published by Oxford University Press on behalf of the Medical Council on Alcohol. All rights reserved

ERYTHROCYTE THIAMINE (Th) ESTERS: A MAJOR FACTOR OF THE ALCOHOL WITHDRAWAL SYNDROME OR A CANDIDATE MARKER FOR ALCOHOLISM ITSELF?

M. CECCANTI*, R. MANCINELLI1, G. F. SASSO, J. P. ALLEN2, R. BINETTI1, A. MELLINI, F. ATTILIA, L. TOPPO and M. L. ATTILIA

Alcohol Unit, University La Sapienza, Rome, Italy, 1 Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy and 2 Pacific Institute for Research and Evaluation, Calverton, MD, USA

* Author to whom correspondence should be addressed at: Mauro Ceccanti, M.D., Dipartimento di Medicina Clinica, Policlinico U.I, Viale del Policlinico 155, 00100 Roma. Fax: 0039-06-49972096; E-mail: mauro.ceccanti{at}uniroma1.it

(First received 30 November 2004; returned 17 December 2004; revised 15 February 2005; accepted 21 March 2005)

Aims: Thiamine (Th) deficiency is a major problem in alcoholics. In this study, the relationship of alcohol withdrawal syndrome (AWS) to Th and its esters, as well as the diagnostic power of Th and its esters were investigated. Patients and methods: Th and its esters were assessed in a series of chronic alcoholics (and in controls) using an improved method. Results: No association was found between AWS severity and Th and its esters, while the diagnostic power of thiamine diphosphate (TDP) and Th was very high. TDP was the most significant among the parameters under study, confirming that erythrocyte TDP is a suitable marker of alcoholism: TDP sensitivity across subjects was 84.1%, specificity 85.4%, positive predictive value 82.4%, and negative predictive value 88.0%.


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R. Mancinelli and M. Ceccanti
Biomarkers in Alcohol Misuse: Their Role in the Prevention and Detection of Thiamine Deficiency
Alcohol Alcohol., March 1, 2009; 44(2): 177 - 182.
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