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Alcohol and Alcoholism Advance Access originally published online on December 13, 2004
Alcohol and Alcoholism 2005 40(2):151-154; doi:10.1093/alcalc/agh127
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Alcohol & Alcoholism Vol. 40, No. 2 © Medical Council on Alcohol 2005; all rights reserved

CASE REPORT

ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF WERNICKE–KORSAKOFF SYNDROME–THREE FURTHER CASES SHOW RESPONSE TO DONEPEZIL

MURRAY COCHRANE, ASHLEY COCHRANE, PRAMOD JAUHAR* and ELIZABETH ASHTON

Parkhead Hospital, 81 Salamanca Street, Glasgow, G31 5ES, UK

* Author to whom correspondence should be addressed at: Parkhead Hospital, 81 Salamanca Street, Glasgow, G31 5ES, UK. Tel: +44(0)141 211 8359; Fax: +44(0)141 211 8431. E-mail: Pramod.Jauhar{at}glacomen.scot.nhs.uk

(Received 23 April 2004; first review notified 5 June 2004; accepted in revised form 1 November 2004)

Three patients diagnosed with Wernicke–Korsakoff syndrome were treated with the acetylcholinesterase inhibitor, donepezil, for periods of 6 to 8 months. Cognitive testing [Alzheimer's disease assessment scale–cognitive subscale (ADAS–Cog), Mini-mental state examination (MMSE), Clock drawing test and six item 2 min recall] and carer questionnaires [Informant Questionnaire (IQ Code), Neuropsychiatric inventory scale (NPI)] were performed at baseline, mid- and endpoint of the treatment period and post-discontinuation. Progressive partial improvement occurred in cognitive measurements through the treatment period, some of which was sustained after discontinuing donepezil. Carer questionnaires also indicated improvement. Confounding factors necessitate caution when attributing improvements to the medication, but these cases suggest that this option merits further investigation.


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