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Alcohol and Alcoholism Advance Access originally published online on January 10, 2005
Alcohol and Alcoholism 2005 40(2):102-105; doi:10.1093/alcalc/agh132
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Alcohol & Alcoholism Vol. 40, No. 2 © Medical Council on Alcohol 2005; all rights reserved

A DAILY GLASS OF RED WINE: DOES IT AFFECT MARKERS OF INFLAMMATION?

LARS RETTERSTOL1,*, KNUT ERIK BERGE1, ØIVIND BRAATEN1, LARS EIKVAR2, TERJE R. PEDERSEN3 and LEIV SANDVIK4

1 Department of Medical Genetics, 2 Department of Clinical Chemistry, 3 Center of Preventive Medicine and 4 Research Center, Ullevål University Hospital, 0407 Oslo, Norway

* Author to whom correspondence should be addressed at: Department of Medical Genetics, Ullevål University Hospital, 0407 Oslo, Norway. Tel.: +47 22119860; Fax: +47 22119899; E-mail: l.j.retterstol{at}ioks.uio.no

(Received 13 September 2004; first review notified 1 October 2004; in revised form 2 November 2004; accepted 25 November 2004)

Aims: Epidemiological studies have shown that moderate consumption of alcohol is associated with a decreased risk of developing cardiovascular disease, but the causal mechanisms are only partly understood. As inflammation is an important process in the progression of atherosclerosis, we hypothesized that the protective effect of red wine is partly mediated through a reduction in inflammation. Methods: We conducted a randomized controlled crossover trial to study the effect of red wine on the levels of the inflammatory markers serum C-reactive protein (CRP) and plasma fibrinogen in healthy, non-smoking individuals. The subjects were randomized to drink one glass of red wine (150 ml, 15 g alcohol) every day (‘wine period’) or to undergo a period of total abstention from alcohol (‘abstention period’). After 3 weeks they switched intervention group. Eighty-seven volunteers completed the study (mean age 50 years). Results: Red wine did not reduce CRP levels and only marginally reduced fibrinogen levels compared with a similar period without alcohol. Conclusions: Consumption of 150 ml of red wine slightly reduced fibrinogen levels but did not reduce CRP levels.


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