Skip Navigation


Alcohol and Alcoholism Advance Access originally published online on October 21, 2004
Alcohol and Alcoholism 2004 39(6):484-485; doi:10.1093/alcalc/agh096
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
39/6/484    most recent
agh096v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by PERNEY, P.
Right arrow Articles by CORBEAU, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PERNEY, P.
Right arrow Articles by CORBEAU, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Alcohol & Alcoholism Vol. 39, No. 6 © Medical Council on Alcohol 2004; all rights reserved

DIMINISHED CD4+ T CELL SURFACE CCR5 EXPRESSION IN ALCOHOLIC PATIENTS

PASCAL PERNEY1,2,*, PIERRE PORTALÈS2, JACQUES CLOT2, FRANÇOIS BLANC1 and PIERRE CORBEAU2

1 Service de Médecine Interne E and 2 Laboratoire d'Immunologie, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France

* Author to whom correspondence should be addressed at: Service de Médecine Interne E, Hôpital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France. Tel.: +33 467 337026; Fax: +33 467 337869; E-mail: p-perney{at}chu-montpellier.fr

(Received 5 April 2004; first review notified 23 May 2004; in revised form 27 August 2004; accepted 28 August 2004)

Aims: The C–C chemokine receptors, particularly the CCR5, appeared to play an important role in T cell-mediated inflammatory reactions. The aim of our study was to assess the impact of chronic alcohol consumption on the in vivo CCR5 expression. Methods: Fourteen alcoholic men hospitalized for a detoxification programme were prospectively included and compared with 49 age-matched controls. Results: The CD4+ T cell surface CCR5 densities were drastically lower in alcoholic patients [mean, 5319 molecules/cell; 95% confidence interval (CI) 4477–6162] as compared with CCR5 densities of the controls (10 944 molecules/cell [CI 9929–11959]; P < 10–4). Conclusions: Chronic alcohol consumption is associated with a significant decrease of CCR5 expression, which could favour Th1/Th2 imbalance.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.