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Alcohol & Alcoholism Vol. 39, No. 4, pp. 321-324, 2004
Alcohol & Alcoholism Vol. 39, No. 4 © Medical Council on Alcohol 2004; all rights reserved


CASE REPORT

DIFFERENTIAL CEREBRAL AND NEUROPSYCHOLOGICAL CONSEQUENCES IN DIZYGOTIC TWINS WITH PRENATAL ALCOHOL EXPOSURE

A. NARBERHAUS1, D. SEGARRA1,*, M. GIMÉNEZ1, X. CALDÚ1, C. JUNQUÉ1, N. BARGALLÓ2 and F. BOTET3

1 Department of Psychiatry and Clinical Psychobiology, University of Barcelona, 2 Neuroradiology Section, Radiology Department, Centre de Diagnòstic per la imatge (CDI), Hospital Clínic, Faculty of Medicine, University of Barcelona, and 3 Pediatrics Section, Department of Obstetrics and Gynecology, Pediatrics, Radiology and Physics Medicine, Hospital Clínic, Barcelona, Spain

* Author to whom correspondence should be addressed at: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron 171, E-08035 Barcelona, Spain. E-mail: dsegarra{at}ub.edu

(Received 8 December 2003; first review notified 9 January 2004; in revised form 2 March 2004; accepted 2 March 2004)

Aim: To relate structural and functional findings in one adolescent dizygotic twin pair with prenatal alcohol exposure. Method: Neuropsychological and volumetric magnetic resonance studies were carried out on a 13-year-old preterm dizygotic twin pair with prenatal alcohol exposure. Results: Neuropsychological and brain structural findings differed between the twins. The child with the more affected phenotype had large-scale cognitive deficits and presented significant atrophy in several brain structures. Both subjects had white matter volume reductions relative to the whole cerebral volume. Conclusion: The neuropsychological and neuroimaging data reflect long-term consequences of prenatal alcohol exposure.


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