Alcohol & Alcoholism Vol. 39, No. 4, pp. 316-320, 2004
Alcohol & Alcoholism Vol. 39, No. 4 © Medical Council on Alcohol 2004; all rights reserved
ADVANCED GLYCATION END-PRODUCTS IN PATIENTS WITH CHRONIC ALCOHOL MISUSE
2PA
EK PAVEL4
INA2
TA21 Institute of Medical Biochemistry, 2 Institute of Clinical Chemistry and Laboratory Diagnostics, 3 Department for Treatment of Addictions and 4 Institute of Rheumatology, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic and 5 Roche Diagnostics, Penzberg, Germany
* Author to whom correspondence should be addressed at: Institute of Medical Biochemistry, First Faculty of Medicine, Charles University, Kate
inská 32, 121 08 Prague 2, Czech Republic. Tel.: +420 224 964285; Fax: +420 224 964280; E-mail: marta.kalousova{at}seznam.cz
(Received 23 October 2003; in revised form 26 January 2004; accepted 19 February 2004)
Aims: The aim of our study was to determine serum levels of advanced glycation end-products (AGE) in patients with chronic alcohol misuse and to examine their relationship to markers of nutrition and inflammation. Methods: The study group consisted of 23 heavy alcohol drinkers treated for chronic alcohol misuse and 22 healthy controls. Studied parameters included AGE (fluorescence, CML – carboxymethyllysine and pentosidine), lipids, glucose, albumin, leptin, prealbumin, C-reactive protein (CRP) and pregnancy-associated plasma protein A (PAPP-A). Results: AGE fluorescence was significantly higher in chronic alcoholic patients than in healthy subjects (4.3 ± 0.7 x 103 vs 3.7 ± 0.5 x 103 AU/g protein, P < 0.005), while CML was only slightly but not significantly elevated (569.1 ± 106.6 vs 545.5 ± 85.8 µg/l) and pentosidine levels did not differ (105.4 ± 29 vs 102.2 ± 23 nmol/l). In alcoholics, AGE correlate significantly negatively with leptin (r = –0.46, P < 0.05) and pentosidine with prealbumin (r = –0.43, P < 0.05), otherwise there was no relationship between AGE and other biochemical parameters (glucose, cholesterol, albumin, CRP, PAPP-A). Conclusion: Our findings suggest a more complex relationship among advanced glycation, oxidative stress and metabolism of ethanol and their link to nutrition and nutrition-associated parameters. AGE as a result of oxidative stress might be similarly linked to increased cardiovascular risk of heavy alcohol drinkers, as are malnutrition and inflammation; however, further studies are needed to confirm this hypothesis.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. K. Halushka, E. Selvin, J. Lu, A. M. Macgregor, and T. C. Cornish Use of Human Vascular Tissue Microarrays for Measurement of Advanced Glycation Endproducts J. Histochem. Cytochem., June 1, 2009; 57(6): 559 - 566. [Abstract] [Full Text] [PDF]
|
|