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Alcohol & Alcoholism Vol. 39, No. 4, pp. 312-315, 2004
Alcohol & Alcoholism Vol. 39, No. 4 © Medical Council on Alcohol 2004; all rights reserved

ALCOHOL MISUSE INCREASES SERUM ANTIBODIES TO OXIDIZED LDL AND C-REACTIVE PROTEIN

HANNU ALHO1,2, PEKKA SILLANAUKEE3, ANNE KALELA3, OLLI JAAKKOLA3,4, SEPPO LAINE5 and SEPPO T. NIKKARI3,5,*

1 Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, 2 Research Unit of Substance Misuse Medicine, University of Helsinki, Helsinki, 3 Department of Medical Biochemistry, University of Tampere Medical School, Tampere, 4 Institute of Medical Technology, University of Tampere, Tampere and 5 Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland

* Author to whom correspondence should be addressed at: Department of Medical Biochemistry, University of Tampere Medical School, FIN-33014 Tampere, Finland. Tel.: +358 3 215 6692; Fax: +358 3 215 6170; Email: seppo.nikkari{at}uta.fi

(Received 24 November 2003; in revised form 22 January 2004; accepted 17 February 2004)

Aims: To clarify the relationship of alcohol consumption with serum antibodies to oxidized low-density lipoprotein (oxLDL) and the inflammation marker C-reactive protein (CRP). Methods: The study population consisted of 280 men with evidence of alcohol misuse by having self-reported alcohol consumption values over 280 g absolute ethanol per week and 250 age-matched moderate drinkers from a population of Finnish men participating in the FINRISK survey study. Serum samples were analysed for antibodies to oxLDL, C-reactive protein (CRP), total cholesterol, HDL-cholesterol, triglycerides, carbohydrate-deficient transferrin (CDT) and gamma-glutamyl transferase (GGT). The characteristics of the top and bottom half of the alcohol misusers, in regard to weekly alcohol consumption, were compared with the controls. Results: Serum antibody titres to oxLDL were higher in the top half and the levels of CRP, HDL-cholesterol, triglycerides, GGT and CDT were elevated in both the top half and the bottom half of the alcohol misusers, compared to controls. Conclusion: We propose that alcohol misuse may result in increased inflammation leading to oxidation of LDL.


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