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Alcohol & Alcoholism Vol. 39, No. 4, pp. 297-302, 2004
Alcohol & Alcoholism Vol. 39, No. 4 © Medical Council on Alcohol 2004; all rights reserved

DIFFERENCES IN BASAL CANNABINOID CB1 RECEPTOR FUNCTION IN SELECTIVE BRAIN AREAS AND VULNERABILITY TO VOLUNTARY ALCOHOL CONSUMPTION IN FAWN HOODED AND WISTAR RATS

SERGIO ORTIZ, JOSÉ M. OLIVA, SANDRA PÉREZ-RIAL, TOMÁS PALOMO and JORGE MANZANARES*

Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain

* Author to whom correspondence should be addressed at: Servicio de Psiquiatria, Edificio Materno-Infantil, 6° Planta, 613-A, Hospital Universitario 12 de Octubre, Avda de Cordoba s/n, E-28041 Madrid, Spain. Tel.: +91 390 8252; Fax: +91 390 8538; E-mail: jmanzanares6{at}terra.es

(Received 6 November 2003; first review notified 7 January 2004; in revised form 12 March 2004; accepted 18 March 2004)

Aim: To specify the functional activity of cannabinoid CB1 receptor in alcohol-preferring Fawn Hooded and alcohol nonpreferring Wistar rats under naïve conditions. Method: Cannabinoid CB1 (WIN-55,212)-stimulated [35S]-GTP{gamma}s binding autoradiography, and cannabinoid CB1 receptor gene expression were measured in rats of both strains that received only water. Results: Cannabinoid CB1 receptor stimulated [35S]-GTP{gamma}s binding was significantly lower in cingulate cortex (Cg), caudate-putamen (CPu), nucleus accumbens (Acc), ventromedial hypothalamic nucleus (VMN), amygdaloid area (AMG), fields (CA1, CA3) of the hippocampus and dentate gyrus (DG) in Fawn Hooded than in Wistar rats, whereas no differences were found either in substantia nigra pars reticulata (SNr) nor CA2 field of the hippocampus. In addition, cannabinoid CB1 receptor gene expression was lower in Cg, CPu, VMN and CA3 field of the hippocampus in Fawn Hooded than in Wistar rats. Conclusions: We speculate that lower cannabinoid function appears to be related to greater vulnerability to alcohol consumption. Cannabinoid CB1 receptor may represent a key target in the treatment of alcohol dependence.


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