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Alcohol & Alcoholism Vol. 39, No. 4, pp. 287-289, 2004
Alcohol & Alcoholism Vol. 39, No. 4 © Medical Council on Alcohol 2004; all rights reserved

CORTISOL RESPONSE TO BUSPIRONE IN EXTENDED ABSTINENT ALCOHOLICS

YOUNG-HOON KIM1,2, JOO-CHEOL SHIM1,3,*, DEANNA L. KELLY5, JEONG-GOO LEE4, YOUNG-SOO SEO1 and ROBERT R. CONLEY5

1 Department of Psychiatry, 2 Paik Institute for Clinical Research and 3 Pharmacogenomics Research Center, Inje University, Busan and 4 Department of Psychiatry, Dongsuh Hospital, Masan, Korea, and 5 Maryland Psychiatric Research Center, University of Maryland Baltimore, MD, USA

* Author to whom correspondence should be addressed at: Department of Psychiatry, Busan Paik Hospital 633-165 Gaegum-Dong, Busanjin-Gu, Busan 614-735, Republic of Korea. Tel.: +82 51 890 6386; Fax: +82 51 894 2532; E-mail: jooshim{at}inje.ac.kr

(Received 2 January 2004; in revised form 10 February 2004; accepted 26 March 2004)

We evaluated cortisol response to buspirone in extended abstinent alcoholic patients to determine 5-HT1A receptor sensitivity in alcoholism. Alcoholic patients were inpatients with an extended abstinent period of at least 3 months. Alcoholics had a significantly lower cortisol level than did the normal controls from 60 min through to 150 min after administration of 30 mg buspirone. Our results show that cortisol response to buspirone was significantly decreased in alcoholic patients compared to normal controls, reflecting decreased 5-HT1A receptor sensitivity.


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