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Alcohol & Alcoholism Vol. 39, No. 2, pp. 110-112, 2004
Alcohol & Alcoholism Vol. 39, No. 2 © Medical Council on Alcohol 2004; all rights reserved.

CHANGES IN COMPOSITION AND PROPERTIES OF ERYTHROCYTE MEMBRANE IN CHRONIC ALCOHOLICS

M. Parmahamsa, K. Rameswara Reddy and N. Varadacharyulu*

Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, India

* Author to whom correspondence should be addressed at: Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515003, India. E-mail: nchvaradacharyulu{at}yahoo.com

(Received 6 June 2003; first review notified 22 August 2003; in revised form 1 December 2003; accepted 15 December 2003)

Aims and Methods: Alterations in cholesterol and phospholipid contents as well as fluidity and lipid peroxidation in erythrocyte membranes from chronic alcoholic humans were investigated. Results: While an increase in cholesterol with no change in phospholipid content was observed in erythrocyte membranes, the phospholipid content increased with no change in cholesterol in plasma. Conclusions: An increase in microviscosity and a consequent decrease in membrane fluidity were evident from the studies of fluorescent hydrocarbon pyrene mobility in the bilayer of erythrocytes in chronic alcoholics. Also, an enhancement in the lipid peroxidation of erythrocytes from alcoholics is indicative of structural damage of membrane resulting from oxidative stress.


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