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Alcohol and Alcoholism Vol. 38, No. 5, pp. 446-449, 2003
© 2003 Medical Council on Alcohol

RAPID COMMUNICATION

SEROTONIN TRANSPORTER PROMOTER POLYMORPHISM AND DIFFERENCES IN ALCOHOL CONSUMPTION BEHAVIOUR IN A COLLEGE STUDENT POPULATION

Aryeh I. Herman, John W. Philbeck1, Nicholas L. Vasilopoulos1 and Paolo B. Depetrillo*

Unit of Clinical and Biochemical Pharmacology, Laboratory of Clinical Studies, Intramural Research Program, National Institutes on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, and
1 Department of Psychology, George Washington University, Washington, DC, USA

(Received 16 May 2003; first review notified 5 June 2003; in revised form 12 June 2003; accepted 16 June 2003)

Aims and methods: In the present study, differences in alcohol consumption behaviour associated with the presence of the short variant (S) of the serotonin transporter promoter polymorphism (5-HTTLPR) was investigated in a Caucasian subset (n = 204) of 268 college students. Results: Students who were homozygous for the S allele were more likely to engage in binge-drinking behaviour, drank more alcohol per occasion, and reported drinking to get drunk more often. Conclusions: In this Caucasian sample, the 5-HTTLPR strongly influences alcohol consumption in late pubescence.


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