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Alcohol and Alcoholism Vol. 38, No. 5, pp. 411-414, 2003
© 2003 Medical Council on Alcohol

PRIMARY HUMAN HEPATOCYTES ARE PROTECTED AGAINST PROLONGED AND REPEATED EXPOSURE TO ETHANOL BY SILIBININ-DIHEMISUCCINATE

Jos F. Van Pelt*, Chris Verslype, Tina Crabbé, Zahur Zaman1 and Johan Fevery

Department of Liver and Pancreatic Diseases and
1 Department Laboratory Medicine, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium

(Received 30 December 2002; first review notified 21 March 2003; in revised form 2 April 2003; accepted 16 April 2003)

Aims and methods: We investigated the effect of silibinin-C-2',3'-dihydrogensuccinate (SDH) on primary human hepatocytes when exposed to ethanol for 14 days. At regular intervals, the medium was refreshed and liver enzymes and secreted protein in the medium were determined. Results: The ethanol-induced release of lactate dehydrogenase (at 34 mM ethanol) was completely blocked by 20 µM SDH. SDH itself stimulated fibrinogen release and had no toxic effect. Conclusions: We can conclude that SDH has a beneficial effect on human hepatocytes when exposed to ethanol in vitro.


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