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Alcohol and Alcoholism Vol. 38, No. 4, pp. 310-315, 2003
© 2003 Medical Council on Alcohol

LACK OF IFENPRODIL ANXIOLYTIC ACTIVITY AFTER ITS MULTIPLE TREATMENT IN CHRONICALLY ETHANOL-TREATED RATS

P. Mikolajczak*, I. Okulicz-Kozaryn, E. Kaminska, M. Szulc, W. Dyr1 and W. Kostowski1

Department of Pharmacology, K. Marcinkowski University of Medical Sciences, Rokietnicka 5a, 60-806 Poznan and
1 Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Al. Sobieskiego 1-9, 02-957 Warsaw, Poland

Received 7 February 2002; in revised form 18 December 2002; accepted 27 February 2003

Aims: The purpose of this study was to assess the anxiolytic activity of ifenprodil in Warsaw high-preferring (WHP) and low-preferring (WLP) rats after chronic ethanol treatment. Methods: WHP and WLP animals, their paired-ethanol-naive groups and control Wistar rats were treated with ifenprodil (1.0 mg/kg, intraperitoneally) for 21 consecutive days. Anxiolytic activity was evaluated by using the two-compartment exploratory test. In addition, the locomotor activity paradigm was also assessed. Results: Ifenprodil did not affect this paradigm in all investigated groups. The ethanol treatment led to lowering of anxiolytic scores in WHP rats. Multiple ifenprodil administration showed an anxiogenic-like activity in both WHP- and WLP-ethanol-treated groups. Conclusions: Our results suggest that, under some conditions, the role of ifenprodil in the treatment of alcoholism may be insufficient to support its use.


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