Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Rogowski, A.
Right arrow Articles by Bienkowski, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rogowski, A.
Right arrow Articles by Bienkowski, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Alcohol and Alcoholism Vol. 38, No. 4, pp. 305-309, 2003
© 2003 Medical Council on Alcohol

RELATIONSHIP BETWEEN DOPAMINE D2 RECEPTOR-ASSOCIATED RESPONSES AND OPERANT ETHANOL SELF-ADMINISTRATION IN THE RAT: A FACTOR ANALYSIS

Artur Rogowski1, Dariusz Rokicki2, Wojciech Kostowski1,3 and Przemyslaw Bienkowski1,*

1 Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9 St., PL-02957 Warszawa,
2 Medagro International, Warszawa and
3 Department of Experimental and Clinical Pharmacology, Warsaw Medical Academy, Warszawa, Poland

Received 4 November 2002; first review notified 15 January 2003; accepted 10 February 2003

Aims: To characterize the relationship between dopamine D2 receptor-associated responses and operant ethanol self-administration in Wistar rats. Methods: Thirty-two rats were first tested for apomorphine-induced sniffing and raclopride-induced catalepsy. Subsequently, the same subjects were initiated to lever press for ethanol in the sucrose-fading procedure. The subjects were allowed to respond for 8% v/v ethanol for 20 days. A factor analysis was used to characterize the relationship between D2-associated responses and parameters of sucrose and ethanol self-administration. Results: The analysis revealed three factors accounting for 88.3% of the total variability. The first factor comprised only parameters of ethanol-reinforced behaviour. Parameters of sucrose self-administration and cataleptic responses to raclopride loaded heavily on the second and third factors, respectively. None of the factors comprised apomorphine-induced stereotypy. Conclusions: It appears that there is no relationship between apomorphine-induced sniffing, raclopride-induced catalepsy and operant responding for ethanol in Wistar rats. Our results, combined with previous reports, suggest that D2 receptors are not primarily involved in the regulation of ethanol reinforcement.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.