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Alcohol and Alcoholism Vol. 38, No. 2, pp. 189-193, 2003
© 2003 Medical Council on Alcohol

RAPID COMMUNICATION

IMPAIRED SERUM CORTISOL STRESS RESPONSE IS A PREDICTOR OF EARLY RELAPSE

K. Junghanns1,*, J. Backhaus1, U. Tietz1, W. Lange2, J. Bernzen3, T. Wetterling4, L. Rink5 and M. Driessen2

1 Department of Psychiatry and Psychotherapy, University of Luebeck,
2 Gilead IV, Psychiatric Hospital, Bielefeld,
3 Clinic Holstein, Luebeck,
4 Department of Psychiatry and Psychotherapy, University of Frankfurt/Main and
5 Institute of Immunology, University of Aachen, Germany

Received 1 October 2002; first review notified 14 November 2002; accepted 18 November 2002

— Aims: to investigate a possible association of cortisol stress response during early abstention with relapse. Methods: Thirty-six alcohol-dependent males, half of them with a comorbid anxiety disorder, and 15 healthy controls were exposed to a standardized psychosocial stress test. Thirty-one of the patients were assessed for relapse 6 weeks after discharge. Results: The relapsers showed almost no cortisol responses in the stress test. Comorbid anxiety disorder influenced neither stress response nor relapse. Conclusions: During early abstention from alcohol, reduced stress-responsivity of the hypothalamo–pituitary–adrenocortical axis seems to be connected to early relapse.


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