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Alcohol and Alcoholism Vol. 38, No. 1, pp. 25-30, 2003
© 2003 Medical Council on Alcohol

PLATELET CD62p EXPRESSION AND MICROPARTICLE FORMATION IN MURINE ACQUIRED IMMUNE DEFICIENCY SYNDROME AND CHRONIC ETHANOL CONSUMPTION

Yinhong Chen1,2, Grace Davis-Gorman2, Ronald R. Watson1,* and Paul F. McDonagh2

1 Divison of Health Promotion Science, College of Public Health and
2 Cardiovascular and Thoracic Surgery, College of Medicine and The Sarver Heart Center, University of Arizona, Tucson, AZ 85724, USA

Received 23 November 2001; first review notified 14 July 2002; accepted 30 July 2002

— Aims: Abnormal platelet counts have been noticed in acquired immune deficiency syndrome (AIDS) patients. However, the actual state of platelets in AIDS is unclear. We hypothesize that platelets are activated and platelet-derived microparticles increase in murine AIDS. Methods: To elucidate the ethanol effects on platelets in murine AIDS, we studied four groups: control, murine AIDS, ethanol, and ethanol plus murine AIDS. Platelet CD62p as a platelet activation marker and CD61+ microparticles as platelet microparticles (PMPs) were measured by flow cytometry. Results: Platelets were significantly activated in mice with murine AIDS and chronic ethanol consumption. Increased platelet CD62p expression and increased PMPs were most pronounced in advanced stages of murine AIDS. Chronic ethanol consumption persistently enhanced platelet activation and PMP formation. Conclusions: Elevated platelet CD62p and PMPs may represent a pro-thrombotic status that have important pathological consequences.


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