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Alcohol and Alcoholism Vol. 37, No. 6, pp. 586-590, 2002
© 2002 Medical Council on Alcohol

LONG-TERM ABSTINENT ALCOHOLICS HAVE A BLUNTED BLOOD GLUCOSE RESPONSE TO 2-DEOXY-D-GLUCOSE

John C. Umhau*, Sarah G. Petrulis, Rosalyn Diaz, Patti A. Riggs, James R. Biddison and David T. George

National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA

Received 30 October 2001; in revised form 26 March 2002; accepted 5 May 2002

— Aims: In this study we explored the relationship between alcohol and carbohydrate consumption in long-term abstinent alcoholics. Methods: We employed an established laboratory paradigm which allowed us to stimulate and measure dietary intake. 2-Deoxy-d-glucose (2-DG) is a glucose analogue that causes an intracellular energy deprivation resulting in exaggerated food consumption and a compensatory metabolic response to raise blood glucose. Using a double-blind design, we gave an infusion of 25 mg/kg 2-DG or placebo to 20 long-term abstinent alcoholics and 19 healthy volunteers. Results: There were no baseline differences in any dietary, behavioural or biochemical variables. As expected, 2-DG increased caloric consumption and blood glucose levels in a time-dependent fashion. There were no differences in food consumption between the alcoholics and the healthy volunteers following the 2-DG stimulus. However, the alcoholic group had a significantly blunted response in blood glucose. Conclusions: The origin of this atypical blood glucose response may antedate the onset of alcoholism, or it may be secondary to alcohol-related damage that persists beyond 6 months. Previous accounts of increased sweet consumption in alcoholics were not substantiated, although they may be present in the peri-withdrawal period.


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LONG-TERM ABSTINENT ALCOHOLICS HAVE A BLUNTED BLOOD GLUCOSE RESPONSE TO 2-DEOXY-D-GLUCOSE
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