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Alcohol and Alcoholism Vol. 37, No. 6, pp. 561-565, 2002
© 2002 Medical Council on Alcohol

PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE ACTIVITY IS INCREASED IN RAT INTESTINAL BRUSH-BORDER MEMBRANE BY CHRONIC ETHANOL INGESTION

Valéria Cristina Soares Furtado, Christina Maeda Takiya and Valeria Bender Braulio*

Division of Nutrition and Metabolism, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

Received 28 March 2002; first review notified 28 May 2002; accepted 26 June 2002

Aims: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine. The aim of this study was to evaluate the effect of chronic ethanol ingestion on PEMT activity in the jejunal brush-border membrane (BBM) of adequately nourished rats. Methods: For this purpose, rats were fed a liquid diet containing ethanol [ethanol-fed group (EFG)] or an isocaloric liquid diet without ethanol [pair-fed group (PFG)] for 4 weeks. Diet ingestion, body weight, nitrogen balance and urinary creatinine excretion were monitored during the experimental period, and serum transferrin levels were determined at the end. BBM was isolated for the determination of PEMT activity. Results: PEMT activity was significantly increased in the jejunal BBM of the EFG. Nutritional parameters, however, did not differ between groups. Conclusions: The increase in PEMT activity may be attributed exclusively to chronic ethanol ingestion, since a major nutritional deficit was excluded.


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