Alcohol and Alcoholism Vol. 37, No. 5, pp. 499-503, 2002
© 2002 Medical Council on Alcohol
PROCEEDINGS OF A SYMPOSIUM ENTITLED: 'GABAB RECEPTORS: A TARGET OF NEW TREATMENTS FOR ALCOHOLISM AND DRUG ABUSE'
THE GABAB RECEPTOR AGONISTS BACLOFEN AND CGP 44532 PREVENT ACQUISITION OF ALCOHOL DRINKING BEHAVIOUR IN ALCOHOL-PREFERRING RATS
1 C.N.R. Institute of Neurogenetics and Neuropharmacology, Cagliari,
2 Neuroscienze S.c.a r.l., Cagliari,
3 Institute of Internal Medicine, Catholic University of Rome, Rome, Italy,
4 Research Department, Novartis Pharma AG, Basel, Switzerland and
5 ‘Bernard B. Brodie’ Department of Neuroscience, University of Cagliari, Cagliari, Italy
Received 23 January 2002; first review notified 26 March 2002; accepted 27 March 2002
ABSTRACT
— Aims: The present study investigated the effect of the 
-aminobutyric acid (GABA)B receptor agonists, baclofen and CGP 44532, on the acquisition of alcohol drinking behaviour in selectively bred Sardinian alcohol-preferring (sP) rats. Methods: Baclofen [0, 1 and 3 mg/kg, intraperitoneally (i.p.)] and CGP 44532 (0, 0.1, 0.3 and 1 mg/kg, i.p.) were administered immediately before alcohol presentation to alcohol-naive sP rats. Alcohol was offered under the two-bottle free-choice regimen with unlimited access for 24 h/day. Drug treatment was repeated once daily for 10 consecutive days. Results: Baclofen and CGP 44532, dose-dependently and with comparable efficacy, suppressed alcohol intake; compensatory increases in water intake left total fluid intakes virtually unchanged. Conclusions: These results demonstrate that baclofen and CGP 44532 prevent the acquisition of alcohol drinking behaviour in sP rats, and suggest the involvement of the GABAB receptor in the mechanisms underlying the disclosure and experience of the reinforcing properties of alcohol in this rat line.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. L. GESSA, S. SERRA, G. VACCA, M. A. M. CARAI, and G. COLOMBO SUPPRESSING EFFECT OF THE CANNABINOID CB1 RECEPTOR ANTAGONIST, SR147778, ON ALCOHOL INTAKE AND MOTIVATIONAL PROPERTIES OF ALCOHOL IN ALCOHOL-PREFERRING sP RATS Alcohol Alcohol., January 1, 2005; 40(1): 46 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Addolorato, F. Caputo, E. Capristo, M. Domenicali, M. Bernardi, L. Janiri, R. Agabio, G. Colombo, G. L. Gessa, and G. Gasbarrini BACLOFEN EFFICACY IN REDUCING ALCOHOL CRAVING AND INTAKE: A PRELIMINARY DOUBLE-BLIND RANDOMIZED CONTROLLED STUDY Alcohol Alcohol., September 1, 2002; 37(5): 504 - 508. [Abstract] [Full Text] [PDF]
|
|