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Alcohol and Alcoholism Vol. 37, No. 4, pp. 340-343, 2002
© 2002 Medical Council on Alcohol

PLATELET MONOAMINE OXIDASE-B ACTIVITY IN TYPE 1 ALCOHOL-DEPENDENT SUBJECTS IN SUSTAINED FULL REMISSION

Ulf Berggren, Matts Eriksson, Claudia Fahlke,1,*, Kaj Blennow, Anders Sundkler and Jan Balldin

The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Psychiatric Section, Sahlgrenska University Hospital/Mölndal, SE-431 80 Mölndal and
1 Department of Psychology, Göteborg University, P. O. Box 500, SE-405 30 Göteborg, Sweden

Received 22 October 2001; accepted 9 January 2002

— Aims: The present study investigated platelet monoamine oxidase-B (MAO-B) activity in male alcohol-dependent subjects in sustained full remission (minimum 1 year), to exclude possible transient changes in platelet MAO-B activity, which occur up to several months after the end of alcohol intake. Methods: MAO-B activity was examined in 16 alcohol-dependent subjects, characterized as type 1 alcoholics, with an abstinence period of 6 ± 7 years (mean ± SD) and in 12 healthy controls. Results: The long-term abstinent alcohol-dependent subjects did not differ from controls in platelet MAO-B activity. Conclusions: Type 1 male alcohol-dependent subjects appear to have normal platelet MAO-B activity. The possibility, however, cannot be excluded that type 2 long-term abstinent alcoholics may have lower platelet MAO-B activity.


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