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Alcohol and Alcoholism Vol. 37, No. 1, pp. 9-12, 2002
© 2002 Medical Council on Alcohol

RAPID COMMUNICATION

DIFFERENT BLOOD ACETALDEHYDE CONCENTRATION FOLLOWING ETHANOL ADMINISTRATION IN A NEWLY DEVELOPED HIGH ALCOHOL PREFERENCE AND LOW ALCOHOL PREFERENCE RAT MODEL SYSTEM

Minori Nishiguchi, Hiroshi Kinoshita,*, Jamal Mostofa1, Tadaaki Taniguchi, Harumi Ouchi, Takako Minami, Katsuhiko Hatake2, Takao Utsumi3, Hiroyuki Motomura4 and Shigeru Hishida

Department of Legal Medicine and
3 Department of Ophthalmology, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501,
1 Department of Forensic Medicine, Kagawa Medical University, 1750-1, Miki, Kita, Kagawa, 761-0793,
2 Department of Legal Medicine, Nara Medical University, 840, Shijo-cho, Kashihara, Nara, 634-8521 and
4 Forensic Science Laboratory, Hyogo Prefectural Police Headquarters, 4-1, Shimoyamate-dori 5-chome, chuo-ku, kobe, 650-8510, Japan

Received 21 May 2001; first review notified 23 August 2001; accepted 22 September 2001

— A significant difference in blood-acetaldehyde concentration was observed between high alcohol-preference (HAP) rats and low alcohol-preference (LAP) rats, newly developed different alcohol preference lines. This difference of acetaldehyde accumulation may be due to cytosolic aldehyde dehydrogenase (ALDH1) polymorphism, which has been reported previously. As the doses of ethanol we employed are higher than that of voluntary drinking, there may be little direct relationship between acetaldehyde accumulation and alcohol preference. We suggest therefore that the ALDH1 polymorphism is associated with alcohol preference in HAP/LAP lines through some other unidentified mechanism.


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