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Alcohol and Alcoholism Vol. 36, No. 6, pp. 520-524, 2001
© 2001 Medical Council on Alcohol

INCREASED NOVELTY SEEKING AND DECREASED HARM AVOIDANCE IN RATS SHOWING TYPE 2-LIKE BEHAVIOUR FOLLOWING BASAL FOREBRAIN NEURONAL LOSS

Åsa K. Johansson and Stefan Hansen*

Department of Psychology, Göteborg University, Box 500, SE-405 30 Göteborg, Sweden

Received 22 January 2001; first review notified 18 April 2001; accepted 4 May 2001

— Previous research has shown that excitotoxic lesions of the septum, ventral striatum and adjacent areas increase alcohol intake and defensive aggression in the rat. This behavioural constellation resembles that observed in early-onset Type 2 alcoholism. Due to the fact that the prototypical Type 2 alcoholic scores high on novelty seeking and low on harm avoidance, we studied these temperamental traits in rats with basal forebrain lesions. In comparison with controls, such rats showed more exploration (nose-poking) of a hole-board (indicating increased novelty seeking) and less risk assessment behaviour (stretched attend posturing) in an unfamiliar arena (indicating reduced harm avoidance). In both tests the experimental rats showed signs of motor restlessness. The results obtained indicate that basal forebrain neuronal loss may be associated with an enhanced exploratory responsiveness to novel stimuli together with a relative freedom of anticipatory anxiety.


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A. K. Johansson and S. Hansen
NOVELTY SEEKING AND HARM AVOIDANCE IN RELATION TO ALCOHOL DRINKING IN INTACT RATS AND FOLLOWING AXON-SPARING LESIONS TO THE AMYGDALA AND VENTRAL STRIATUM
Alcohol Alcohol., March 1, 2002; 37(2): 147 - 156.
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