Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kinoshita, H.
Right arrow Articles by Ameno, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kinoshita, H.
Right arrow Articles by Ameno, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Alcohol and Alcoholism Vol. 36, No. 5, pp. 377-380, 2001
© 2001 Medical Council on Alcohol

CHOLINERGIC NERVES MEDIATE ACETALDEHYDE ACTION IN THE GASTROINTESTINAL TRACT

Hiroshi Kinoshita,*, Iwao Ijiri1, Setsuko Ameno1, Takako Kubota1, Xia Zhang1, Shigeru Hishida and Kiyoshi Ameno1

Department of Legal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 and
1 Department of Forensic Medicine, Kagawa Medical University, 1750-1, Miki, Kita, Kagawa, 761-0793, Japan

Received 15 March 2000; in revised form 5 March 2001; accepted 31 March 2001

— The regulation mechanism of inhibition of intestinal ethanol absorption induced by high acetaldehyde (AcH) concentration in blood was investigated. We used atropine (AT), atropine methylbromide (ATMB), pirenzepine (PI), bethanechol (BE) and pilocarpine (PL) with or without cyanamide (CY; a potent inhibitor of aldehyde dehydrogenase, which induces high AcH concentration in blood). The Ka (absorption rate constant) value after the CY-alone pretreatment was significantly lower than that in controls. In the high AcH-induced cases, the values of Ka in AT and ATMB pretreatments were similar to controls, but the value of Ka in PI pretreatment was lower than that in controls. The values of Ka in the case of BE pretreatment with and without high AcH levels were lower than in controls. The Ka value in the PL with CY was significantly lower than that with CY alone. However, its action was blocked by ATMB pretreatment. These results suggest that high blood AcH concentrations inhibit intestinal ethanol absorption through the peripheral cholinergic nerves via muscarinic receptors, except for the muscarinic M1 receptor, compared to other subtypes of muscarinic receptors.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
H. Kinoshita, D. S. Jessop, D. J. Roberts, K. Ameno, I. Ijiri, S. Hishida, and M. S. Harbuz
EFFECTS OF ACETALDEHYDE ON c-fos mRNA INDUCTION IN THE PARAVENTRICULAR NUCLEUS FOLLOWING ETHANOL ADMINISTRATION
Alcohol Alcohol., September 1, 2002; 37(5): 432 - 435.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.