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Alcohol and Alcoholism Vol. 36, No. 4, pp. 339-345, 2001
© 2001 Medical Council on Alcoholism

Association of self-reported diseases and health care use with commonly used laboratory markers for alcohol consumption

Pekka Sillanaukee,*, Nuria Strid1,, Pekka Jousilahti2,3,, Erkki Vartiainen2,, Kari Poikolainen4,5,, Seppo Nikkari6,, John P. Allen,7 and Hannu Alho8,9,

FIT Biotech OYj Plc, Tampere, Finland,
1 NS Associates, Vattholma, Sweden,
2 National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki,
3 Tampere School of Public Health, Tampere,
4 Järvenpää Addiction Hospital,
5 National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki,
6 University of Tampere Medical School, Department of Medical Biochemistry, Tampere, Finland,
7 National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA,
8 National Public Health Institute, Alcohol Research Centre, Helsinki and
9 Research Unit of Alcohol Diseases, University of Helsinki, Finland

Received 11 September 2000; first review notified 25 January 2001; accepted 12 February 2001

The relationships of carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT) and their mathematical combination ({gamma}-CDT) with self-reported diseases were evaluated in a large cross-sectional risk factor survey. Significant gender effects were observed in associations of the markers with several medical conditions as well as with general health care utilization. In men, CDT was associated with rheumatoid arthritis. In both genders, GGT was positively associated with hypertension and diabetes. {gamma}-CDT was positively associated with hypertension in males and with asthma in females. This general population study demonstrates that these markers, although most commonly used to assess alcohol misuse, might also serve as health risk indicators.


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