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Alcohol and Alcoholism Vol. 36, No. 3, pp. 219-223, 2001
© 2001 Medical Council on Alcoholism

Comorbid anxiety and affective disorder in alcohol-dependent patients seeking treatment: the first Multicentre Study in Germany

U. Schneider,*, A. Altmann,1, M. Baumann,2, J. Bernzen,3, B. Bertz,4, U. Bimber,5, T. Broese,6, A. Broocks,3, W. Burtscheidt,7, K. F. Cimander,8, P. Degkwitz,9, M. Driessen,3, H. Ehrenreich,1, E. Fischbach,10, H. Folkerts,11, H. Frank,11, D. Gurth,12, U. Havemann-Reinecke,1, W. Heber,13, J. Heuer,10, A. Hingsammer,14, S. Jacobs,1, H. Krampe,1, W. Lange,10, T. Lay,6, M. Leimbach,11, M. R. Lemke,15, M. Leweke,7, A. Mangholz,1, W. Massing,16, R. Meyenberg,14, J. Porzig,1, T. Quattert,17, C. Redner,7, G. Ritzel,17, J. D. Rollnik, R. Sauvageoll,5, D. Schläfke,6, G. Schmid,6, H. Schröder,18, U. Schwichtenberg,19, D. Schwoon,9, J. Seifert, I. Sickelmann, C. F. Sieveking,20, C. Spiess,21, H. H. Stiegemann,17, R. Stracke,12, H. D. Straetgen,22, P. Subkowski,23, R. Thomasius,9, H. Tretzel,4, L. J. Verner, J. Vitens,24, T. Wagner,1, S. Weirich,6, I. Weiss,14, T. Wendorff,15, T. Wetterling,2, B. Wiese and J. Wittfoot,10

Medizinische Hochschule Hannover
1 Georg-August Universität, Göttingen,
2 Johann-Wolfgang-Goethe Universität, Frankfurt,
3 Medizinische Universität, Lübeck,
4 Klinikum der Hansestadt Stralsund,
5 Zentrum für Soziale Psychiatrie, Bad Emstal,
6 Klinik für Psychiatrie und Psychotherapie der Universität Rostock,
7 Psychiatrische Klinik der Heinrich Heine Universität, Düsseldorf,
8 Zentrum für Drogenkranke, Hannover,
9 Universitätskrankenhaus, Hamburg,
10 Gilead, Psychiatrische Klinik, Bielefeld,
11 Reinhard-Nieter Krankenhaus, Wilhelmshaven,
12 Klinikum Nord, Hamburg,
13 Nds. Landeskrankenhaus, Göttingen,
14 Klinik für Psychiatrie und Psychotherapie III des Zentralkrankenhauses Bremen Ost/Universität Oldenburg,
15 Christian-Albrechts Universität, Kiel,
16 Tagesklinik Königstraße, Hannover,
17 Nds. Landeskrankenhaus, Hildesheim,
18 Klinik für Psychiatrie und Psychotherapie, Langenhagen,
19 Nds. Landeskrankenhaus, Osnabrück,
20 Paracelsus-Wiehengebirgsklink, Bad Essen,
21 Charite, Berlin,
22 Fachklinik Holstein, Lübeck,
23 Paracelsus Berghof-klinik, Bad Essen,
24 Nds. Landeskrankenhaus Wehnen, Bad Zwischenahn, Germany

Received 10 July 2000; first review notified 10 November 2000; accepted 10 December 2000

The goals of this study were to describe demographic variables, drinking history, and the 6-month prevalence of Axis I comorbidity among alcohol-dependent subjects in Germany. The variables: amount of alcohol consumption, age at onset of the first alcohol consumed, age at onset of daily alcohol consumption, age at onset of withdrawal symptoms and number of detoxifications were related to the different comorbid disorders and gender. In this study, 556 patients from 25 alcohol treatment centres were enrolled between 1 January 1999 and 30 April 1999. After a minimum of 10 days of sobriety patients who fulfilled ICD-10 and DSM-IV criteria of alcohol dependence were interviewed for data collection using the Mini-DIPS (German version of the Anxiety Disorders Interview Schedule) and a standardized psychosocial interview. The 6-month prevalence of comorbid Axis I disorders was 53.1%. Among the patients with comorbidity, affective and anxiety disorders were most frequent. Comorbid stress disorder was associated with an early start of drinking, an early beginning of withdrawal symptoms, highest number of detoxifications, and the highest amount of alcohol consumed. Female patients with anxiety disorder consumed more alcohol and started earlier than females without this comorbid disorder. The data do not answer the question of the pathogenesis of comorbid disorders and alcoholism, but indicate that stress disorders in alcoholic patients and anxiety disorders in female alcoholics influence the course and severity of alcoholism.


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