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Alcohol and Alcoholism Vol. 36, No. 2, pp. 99-103, 2001
© 2001 Medical Council on Alcoholism

INVITED REVIEW

Genetic association studies of alcoholism — problems with the candidate gene approach

Paul R. Buckland

Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK

Received 17 April 2000; first review notified 21 September 2000;

ABSTRACT

— In recent years, progress has been made in the identification of causative factors in most single gene disorders and those with genes of major effect. In comparison, no genes contributing to a complex disorder have been unambiguously identified. A number of reasons for this have been previously presented in theoretical papers. Alcoholism is such a complex illness and genetic studies into its underlying genetic causes have suffered from lack of power due to small subject numbers, poor selection of control subjects, and over-emphasis on markers with low prior probability of involvement.


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