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Alcohol and Alcoholism Vol. 36, No. 1, pp. 70-74, 2001
© 2001 Medical Council on Alcoholism

Immunoreactivity of cAMP response element binding protein is not altered in the post-mortem cerebral cortex or cerebellum of alcoholics

Megumi Yamamoto*, Sabine Pohli, Nuria Durany, Hiroki Ozawa1, Toshikazu Saito1, Karl W. Boissl2, Robert Zöchling2, Peter Riederer, Jobst Böning and Mario E. Götz

Clinical Neurochemistry, Department of Psychiatry and Psychotherapy, University of Würzburg, Füchsleinstrasse 15, 97080 Würzburg, Germany,
1 Department of Neuropsychiatry, Sapporo Medical University, S.1, W. 16, Chuo-ku, Sapporo, 060-8543 Japan and
2 State Hospital of Psychiatry and Neurology, Mauer, A-3362 Mauer, Austria

Received 28 March 2000; first review notified 19 June 2000; accepted 8 July 2000

— We examined amounts of cAMP response element binding protein (CREB) and its phosphorylated form in post-mortem frontal and temporal cortices and cerebella from alcoholics and controls by immunoblotting. No significant differences were observed in the levels of these proteins in each brain region, suggesting that the assumed neuroadaptations to chronic ethanol intake may not be reflected by quantitative alterations of CREB in alcoholic brain.


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