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Alcohol and Alcoholism Vol. 36, No. 1, pp. 26-28, 2001
© 2001 Medical Council on Alcoholism

RAPID COMMUNICATION

Vitamin B12 and hepatic enzyme serum levels correlate in male alcohol-dependent patients

Hubertus Himmerich*, Ion Anghelescu, Christoph Klawe and Armin Szegedi

Department of Psychiatry, University of Mainz, Untere Zahlbacherstr. 8, D-55131 Mainz, Germany

Received 21 July 2000; accepted 22 August 2000

— Vitamin B12 serum levels and markers for alcohol consumption were determined in 80 male alcohol-dependent patients. Spearman correlation coefficients (rS) were calculated. Significant positive correlations between vitamin B12 and hepatic enzyme values were found (gamma-glutamyltransferase: rS = 0.58; alanine aminotransferase: rS = 0.43; aspartate aminotransferase: rS = 0.47; glutamate dehydrogenase: rS = 0.43; all P < 0.001). Therefore, for a proper interpretation of vitamin B12 levels, it may be clinically relevant to take markers of hepatocellular damage into account.


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