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Alcohol and Alcoholism Vol. 36, No. 1, pp. 22-25, 2001
© 2001 Medical Council on Alcoholism

RAPID COMMUNICATION

Alcohol-induced euphoria: exclusion of serotonin

Christopher J. Morgan and Abdulla A.-B. Badawy*

Cardiff and Vale NHS Trust, Biomedical Research Laboratory, Whitchurch Hospital, Cardiff CF14 7XB, UK

Received 7 April 2000; first review notified 2 July 2000; accepted 22 August 2000

— During the first 30 min after acute ethanol consumption by three fasting normal male volunteers, no increase in circulating tryptophan availability to the brain occurred. On the contrary, a small decrease was observed, which became stronger subsequently. We conclude from this preliminary study that brain serotonin levels are not increased after alcohol intake by normal subjects and that, consequently, this indolylamine is unlikely to mediate the euphoric effects of alcohol.


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