Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Eriksson, M.
Right arrow Articles by Balldin, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eriksson, M.
Right arrow Articles by Balldin, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Alcohol and Alcoholism Vol. 35, No. 5, pp. 493-498, 2000
© 2000 Medical Council on Alcoholism

ALCOHOLICS WITH THE DOPAMINE RECEPTOR DRD2 A1 ALLELE HAVE LOWER PLATELET MONOAMINE OXIDASE-B ACTIVITY THAN THOSE WITH THE A2 ALLELE: A PRELIMINARY STUDY

Matts Eriksson, Ulf Berggren, Kaj Blennow, Claudia Fahlke1, Jan-Erik Månsson and Jan Balldin*

Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Sahlgren University Hospital/Mölndal, Göteborg University, SE-431 80 Mölndal
1 Department of Psychology, Göteborg University, P.O. Box 500, SE-405 30 Göteborg, Sweden

Received 25 January 2000; first review notified 11 April 2000; accepted 28 April 2000

Low platelet monoamine oxidase B (MAO-B) activity and the presence of the Taq1 A1 allele of the dopamine D2 receptor (DRD2) gene have independently been proposed as ‘biological/genetic’ markers for alcoholism. In the present study, the relationship between these two markers was investigated in a group of socially stable Caucasian middle-aged men with a mean (±SD) daily ethanol consumption of 85 ± 57 g. The platelet MAO-B activity was significantly lower in individuals with the DRD2 A1 allele (n = 8), compared to those without it (n = 29). This relationship remained unchanged when including only subjects who fulfilled DSM-IV criteria for alcohol dependence (n = 27). The finding suggests that alcoholics who are carriers of the DRD2 A1 allele may have lower platelet MAO-B activity.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
S. Pombo, P. Levy, M. Bicho, F. Ismail, and J M N. Cardoso
Neuropsychological Function and Platelet Monoamine Oxidase Activity Levels in Type I Alcoholic Patients
Alcohol Alcohol., July 1, 2008; 43(4): 423 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
U. BERGGREN, C. FAHLKE, E. ARONSSON, A. KARANTI, M. ERIKSSON, K. BLENNOW, D. THELLE, H. ZETTERBERG, and J. BALLDIN
THE TAQI DRD2 A1 ALLELE IS ASSOCIATED WITH ALCOHOL-DEPENDENCE ALTHOUGH ITS EFFECT SIZE IS SMALL
Alcohol Alcohol., September 1, 2006; 41(5): 479 - 485.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.