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Alcohol and Alcoholism Vol. 35, No. 5, pp. 424-426, 2000
© 2000 Medical Council on Alcoholism

Rapid Communication

EFFECT OF METHYLENE BLUE ON THE DISPOSITION OF ETHANOL

Ronald Vonlanthen, Jürg H. Beer and Bernhard H. Lauterburg1,*

Department of Medicine, Kantonsspital Baden
1 Department of Clinical Pharmacology, University of Bern, Murtenstrasse 35, CH-3010 Bern, Switzerland

Received 24 February 2000; first review notified 19 May 2000; accepted 23 May 2000

The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [14C]ethanol to 14CO2 in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by the increase in the [lactate]/[pyruvate] ratio.


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