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Alcohol and Alcoholism Vol. 35, No. 4, pp. 390-393, 2000
© 2000 Medical Council on Alcoholism

PLATELET SEROTONIN UPTAKE IS HIGHER IN EARLY-ONSET THAN IN LATE-ONSET ALCOHOLICS

Martin Javors1,2,*, Mohamed Tiouririne1 and Thomas Prihoda1,3

1 Departments of Psychiatry,
2 Pharmacology and
3 Pathology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA

Received 7 December 1999; first review notified 23 March 2000; accepted 28 March 2000

The main objective of this study was to compare platelet serotonin (5-HT) uptake between early-onset alcoholics (EOA) and late-onset alcoholics (LOA). Subjects were 24 dependent male alcoholic in-patients and 21 healthy control subjects. 5-HT uptake was quantified by incubating platelets with [3H]5-HT at various concentrations (0.5 to 1000 nM). 5-HT uptake was higher in EOA, compared to both the LOA and control groups (P < 0.02) at the highest 5-HT concentration (1000 nM). No significant difference was found between LOA and controls or between EOA + LOA and controls. Previous studies have shown that 5-HT uptake was higher in platelets, lymphocytes, and brain of alcoholics vs controls, but our data suggest that higher platelet serotonin transporter function is limited to EOA, not LOA.


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