Alcohol and Alcoholism Vol. 35, No. 4, pp. 377-380, 2000
© 2000 Medical Council on Alcoholism
TRANSIENT INCREASE IN PLATELET MONOAMINE OXIDASE B ACTIVITY DURING EARLY ABSTINENCE IN ALCOHOLICS: IMPLICATIONS FOR RESEARCH
Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Sahlgren University Hospital/Mölndal, Göteborg University, SE-431 80 Mölndal and
1 Department of Psychology, Göteborg University, P.O. Box 500, SE-405 30 Göteborg, Sweden
Received 29 November 1999; in revised form 8 March 2000; accepted 27 March 2000
Some earlier studies have suggested that platelet monoamine oxidase (MAO)-B activity should be determined at time points other than early in the abstinence phase. However, the optimal times for blood sampling have not been precisely defined. We therefore assessed platelet MAO-B activity repeatedly in 13 male alcohol-dependent patients over the 2 months after the end of a period of heavy alcohol intake. Twelve healthy men were used as controls. In the alcohol-dependent patients, platelet MAO-B activity was transiently increased from 2 to 6 weeks after the end of alcohol intake and the values during this time period were not different from those of controls. Platelet MAO-B activity was, however, significantly lower in the alcohol-dependent patients at 1 week and at 2 months after the end of alcohol intake, in comparison to controls. It is concluded that the transient increase in platelet MAO-B activity after the end of alcohol intake in alcohol-dependent patients may conceal a difference from a control group. Therefore, it is suggested that when platelet MAO-B activity is determined, the preferential time point for obtaining those values in alcohol-dependent patients is after 2 months of abstinence.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Pombo, P. Levy, M. Bicho, F. Ismail, and J M N. Cardoso Neuropsychological Function and Platelet Monoamine Oxidase Activity Levels in Type I Alcoholic Patients Alcohol Alcohol., July 1, 2008; 43(4): 423 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Berggren, M. Eriksson, C. Fahlke, K. Blennow, and J. Balldin Different effects of smoking or use of smokeless tobacco on platelet MAO-B activity in type 1 alcohol-dependent subjects Alcohol Alcohol., May 1, 2007; 42(3): 267 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Coccini, A. F. Castoldi, C. Gandini, G. Randine, G. Vittadini, P. Baiardi, and L. Manzo PLATELET MONOAMINE OXIDASE B ACTIVITY AS A STATE MARKER FOR ALCOHOLISM: TREND OVER TIME DURING WITHDRAWAL AND INFLUENCE OF SMOKING AND GENDER Alcohol Alcohol., November 1, 2002; 37(6): 566 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Demir, G. Ucar, B. Ulug, S. Ulusoy, I. Sevinc, and S. Batur PLATELET MONOAMINE OXIDASE ACTIVITY IN ALCOHOLISM SUBTYPES: RELATIONSHIP TO PERSONALITY TRAITS AND EXECUTIVE FUNCTIONS Alcohol Alcohol., November 1, 2002; 37(6): 597 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Berggren, M. Eriksson, C. Fahlke, K. Blennow, A. Sundkler, and J. Balldin PLATELET MONOAMINE OXIDASE-B ACTIVITY IN TYPE 1 ALCOHOL-DEPENDENT SUBJECTS IN SUSTAINED FULL REMISSION Alcohol Alcohol., July 1, 2002; 37(4): 340 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Esel, K. Kose, M. T. Turan, M. Basturk, S. Sofuoglu, S. S. Aslan, I. Yabanoglu, A. S. Gonul, and C. Yazici MONOAMINE OXIDASE-B ACTIVITY IN ALCOHOL WITHDRAWAL OF SMOKERS: IS THERE ANY RELATIONSHIP WITH AGGRESSIVENESS? Alcohol Alcohol., May 1, 2002; 37(3): 272 - 276. [Abstract] [Full Text] [PDF]
|
|