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Alcohol and Alcoholism Vol. 35, No. 4, pp. 331-335, 2000
© 2000 Medical Council on Alcoholism

ROLE OF ACETALDEHYDE IN THE INDUCTION OF HEART LEFT VENTRICULAR ATRIAL NATRIURETIC PEPTIDE GENE EXPRESSION IN RATS

Heidi Jänkälä, C. J. Peter Eriksson1, Niels Erik Petersen2, Matti Härkönen and Tiina Mäki*

Department of Clinical Chemistry, Helsinki University Central Hospital, Haartmaninkatu 4, SF-00290 Helsinki,
1 Department of Mental Health and Alcohol Research, (C.J.P.E.) National Public Health Institute, PL 719, SF-00101 Helsinki, Finland and
2 Department of Clinical Chemistry, Odense University Hospital, Odense, Denmark

Received 23 August 1999; first review notified 14 February 2000; accepted 17 February 2000

We studied the effects of ethanol and acetaldehyde on myocardial gene expression of atrial natriuretic peptide (ANP) and growth of rats. Combined ethanol and calcium carbimide treatment increased blood-acetaldehyde levels and ANP mRNA levels by 40–60% in 2–8 day experiments, compared to the controls. The results suggest a role for acetaldehyde in the development of alcoholic heart dysfunction.


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