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Alcohol and Alcoholism Vol. 35, No. 3, pp. 302-306, 2000
© 2000 Medical Council on Alcoholism

FREQUENCY AND MARKOV CHAIN ANALYSIS OF THE AMINO-ACID SEQUENCE OF HUMAN ALCOHOL DEHYDROGENASE {alpha}-CHAIN

GUANG WU*

Service of Clinical Pharmacology and Toxicology, Medical School, University of Udine, Piazzale Santa Maria della Misericordia, I-33100 Udine, Italy

Received 27 September 1999; first review notified 17 December 1999; accepted 20 December 1999

The amino-acid sequences of human alcohol dehydrogenase {alpha}-chain (ADH1) were analysed according to two-, three- and four-amino-acid sequences. The measured frequencies and probabilities were compared with the predicted frequencies and probabilities. Of 373 two-amino-acid sequences in the ADH1, 92 (24.665%) and 32 (8.579%) sequences can be explained by the predicted frequencies and probabilities according to a purely random mechanism. Of 191 non-appearing two-amino-acid sequences in the ADH1, 119 (62.304%) and 52 (27.225%) sequences can be explained by the predicted frequencies and probabilities according to a purely random mechanism. Of 373 measured first-order Markov transition probabilities for the second amino acid in two-amino-acid sequences, three (0.804%) probabilities match the predicted conditional probabilities and therefore can be explained by a purely random mechanism. No more-than-two-amino-acid sequences can be explained by a purely random mechanism.


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