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Alcohol and Alcoholism Vol. 35, No. 3, pp. 296-301, 2000
© 2000 Medical Council on Alcoholism

DRINKING HABITS OF SUBJECTS WITH HEPATITIS C VIRUS-RELATED CHRONIC LIVER DISEASE: PREVALENCE AND EFFECT ON CLINICAL, VIROLOGICAL AND PATHOLOGICAL ASPECTS

CARMELA LOGUERCIO1,*, MAURO DI PIERRO1, MARIA PIA DI MARINO2, ALESSANDRO FEDERICO3, DONATO DISALVO4, ENY CRAFA1, CONCETTA TUCCILLO1, FELICIANO BALDI2 and CAMILLO DEL VECCHIO BLANCO1,3

Cattedra di
1 Gastroenterologia ed
2 Anatomia Patologica,
3 CIRANAD (Centro Interuniversitario Ricerche Alimenti, Nutrizione e Apparato Digerente), II Università di Napoli and
4 Azienda Ospedaliera ASL 3, Villa D'Agri, Potenza, Italy

Received 7 July 1999; first review notified 7 December 1999; accepted 6 January 2000

Alcohol changes the progression of hepatitis C virus (HCV)-related chronic liver disease and may affect the outcome of interferon therapy. The ethanol intake of 245 patients with biopsy-proven chronic hepatitis C with or without cirrhosis, its interaction with laboratory and histological parameters common to alcohol and HCV-mediated liver damage, and its effects on therapy were evaluated. The results show that 60–70% of subjects regularly consumed alcohol (median intake >40 g/day in about 30%). Less than 50% stopped drinking after being diagnosed as having liver disease. Ethanol intake affected: fibrosis, especially in women, HCV RNA levels, which were significantly lower in abstainers than in drinkers (0.6 ± 0.3 vs 6.9 ± 5.9 Eq/ml x106; P < 0.01), and response to interferon therapy. The number of responders decreased as ethanol intake increased. There were less abstainers than drinkers among non-responders (10.7% vs 63.1% respectively; P < 0.001). Data indicate that alcohol will induce and worsen liver damage and, in subjects with chronic liver disease who continue to drink, adversely affect their response to treatment.


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