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Alcohol and Alcoholism Vol. 35, No. 1, pp. 49-51, 2000
© 2000 Medical Council on Alcoholism

A PILOT INVESTIGATION OF THE EFFECT OF TRYPTOPHAN MANIPULATION ON THE AFFECTIVE STATE OF MALE CHRONIC ALCOHOLICS

Colin R. Martin* and Adrian B. Bonner1

Hull and East Yorkshire Hospitals NHS Trust, Institute of Rehabilitation, 215 Anlaby Road, Hull HU3 2PG and
1 Division of Psychiatry, Kent Institute of Medicine and Health Sciences, University of Kent at Canterbury, Canterbury, Kent CT2 7PD, UK

Received 12 January 1999; first review notified 18 March 1999; accepted 25 April 1999

A pilot study was conducted to investigate the hypothesis that dietary tryptophan manipulation would influence self-report affective status in alcoholic males. No significant effect of dietary manipulation was observed on the tryptophan/large neutral amino acids ratio or psychological indices of affect. The notion that dietary manipulation may be utilized in improving mood state in alcoholic males was not supported.


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