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Alcohol and Alcoholism Vol. 35, No. 1, pp. 44-48, 2000
© 2000 Medical Council on Alcoholism

EFFECTS OF CARNOSINE AND RELATED COMPOUNDS ON THE STABILITY AND MORPHOLOGY OF ERYTHROCYTES FROM ALCOHOLICS

V. D. Prokopieva1, N. A. Bohan1, P. Johnson2,*, H. Abe3 and A. A. Boldyrev4

1 Mental Health Research Institute, Medical Academy of Sciences of Russia, Tomsk, Russia,
2 Department of Chemistry and Biochemistry and Department of Biomedical Sciences, Ohio University, Athens, OH 45701, USA,
3 Laboratory of Marine Biochemistry, University of Tokyo, Bunkyo-ky, Tokyo 113–8567, Japan and
4 Department of Biochemistry, International Biotechnological Center of M. V. Lomonosov Moscow State University, 199899 Moscow, Russia

Received 18 September 1998; first review notified 25 January 1999; accepted 16 March 1999

The effects of carnosine and related compounds on erythrocytes from alcoholics were studied. In their presence, erythrocytes showed an increased ability to resist haemolysis and showed a more normal morphology, with carnosine and N-acetyl-carnosine being the most effective compounds. These beneficial properties of the dipeptides do not appear to be directly related to their antioxidant or buffering properties.


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