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Alcohol and Alcoholism Vol. 34, No. 5, pp. 750-759, 1999
© 1999 Medical Council on Alcoholism

PSYCHOPATHOLOGY IN ALCOHOL WITHDRAWAL: RELATIONSHIP TO {alpha}2-ADRENOCEPTOR FUNCTION

Claudia Fahlke, Ulf Berggren1, Christopher Lundborg1 and Jan Balldin1,*

Department of Psychology, PO Box 500, SE-405 30 Göteborg and
1 Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Unit for Research on Alcoholism and Substance Abuse, Sahlgrenska University Hospital/Mölndal, SE-431 80 Mölndal, Göteborg University, Sweden

Received 16 September 1998; first review notified 25 January 1999; accepted 16 March 1999

The possible relationship between postsynaptic {alpha}2-adrenoceptor function, as assessed by growth hormone (GH) response to clonidine (CLON; 1.5 or 2.0 µg/kg i.v.), and psychopathology was investigated in 30 patients with alcohol-dependence in the early withdrawal period. Excluding patients with high baseline GH, 23 of the 26 patients had blunted GH responses to CLON and 57% moderate or severe depression at day 1 after the end of alcohol intake. After 1 week, the GH responses to CLON remained blunted in 20 of 21 retested patients, whereas the depression and anxiety remitted in all but two patients. The results do not support any relationship between postsynaptic {alpha}2-adrenoceptor function and symptoms of psychopathology in alcohol withdrawal.


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