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Alcohol and Alcoholism Vol. 34, No. 5, pp. 726-732, 1999
© 1999 Medical Council on Alcoholism

PLATELET SEROTONERGIC BINDING SITES IN ALCOHOL-DEPENDENT PATIENTS

Belén Arranz, Pilar Rosel1, Salvador Sarró, Encarna Zaldivar, Ramón Cano, Miguel Angel Navarro1 and Luis San*

Benito Menni, Mental Health Care Institute, Barcelona and
1 Hormone Unit, Department of Biochemistry, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain

Received 23 September 1998; first review notified 13 January 1999; accepted 8 March 1999

The serotonin (5-hydroxytryptamine, 5-HT) uptake sites assessed with both [3H]imipramine and [3H]paroxetine, and the 5-HT2A receptors were simultaneously measured in platelets from 24 male subjects meeting the American Psychiatric Association's DSM-IV criteria for alcohol dependence and admitted for inpatient detoxification. Blood samples from alcoholic patients were collected during acute alcohol intoxication (day 0), during withdrawal (day 1), and after 2 weeks of abstinence (day 14). All patients met the criteria for type II alcoholism. Alcohol misuse was found to be associated with an increased number and a lower affinity of [3H]paroxetine binding in comparison to the control values. Abstinence from alcohol for 2 weeks (day 14) resulted in a decrease in the number of 5-HT uptake sites labelled with [3H]paroxetine compared to normal values, together with a significant decrease in the number of 5-HT2A binding sites. The present data indicate that altered serotonergic function existing in alcoholic patients is a reversible phenomenon that normalizes after detoxification and withdrawal.


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