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Alcohol and Alcoholism Vol. 34, No. 5, pp. 678-684, 1999
© 1999 Medical Council on Alcoholism

Rapid Communication

CHRONIC ALCOHOL CONSUMPTION INCREASES SERUM LEVELS OF CIRCULATING ENDOTHELIAL CELL/LEUCOCYTE ADHESION MOLECULES E-SELECTIN AND ICAM-1

E. Sacanella, R. Estruch*, E. Badía, J. Fernández-Sola, J. M. Nicolás and A. Urbano-Márquez

Department of Internal Medicine, Hospital Clínic, Institut d'Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

Received 29 January 1999; in revised form 12 April 1999; accepted 24 April 1999

A group of 30 chronic alcoholics without alcohol-related diseases and 30 controls (teetotallers) were selected to measure serum levels of endothelial adhesion molecules (AMs) (ICAM-1, VCAM-1, and E-selectin). ICAM-1 and E-selectin serum levels were higher in alcoholics, whereas VCAM-1 serum levels were similar in both groups. There was a significant correlation between daily alcohol intake and serum level of ICAM-1 (r = 0.49, P = 0.003) and E-selectin (r = 0.41, P = 0.02). A significant positive correlation between E-selectin and total lifetime dose of ethanol was also observed (r = 0.52, P = 0.003). These changes in serum levels of endothelial AMs of chronic alcoholics may reflect endothelial and/or immune activation, and could interfere with the reactions between immune cells and the endothelium.


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