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Alcohol and Alcoholism Vol. 34, No. 4, pp. 511-519, 1999
© 1999 Medical Council on Alcoholism

ZOLPIDEM INVOLVEMENT ON MEMORY AND HYPNOTIC EFFECT OF ETHANOL IN CHRONICALLY ETHANOL-TREATED RATS

P. Mikolajczak*, I. Okulicz-Kozaryn, K. Szczawinska, E. Kaminska and K. Kus

Department of Pharmacology, University of Medical Sciences in Poznan, Fredry 10, 61–701 Poznan, Poland

Received 24 December 1997; in revised form 5 November 1998; accepted 11 December 1998

Multiple (10x) treatment of zolpidem (1.0 or 2.0 mg/kg, orally, p.o.) led to different effects in chronically ethanol-treated and control rats. In control rats, after repeated zolpidem administration, a weaker, when compared to single administration, hypnotic effect of ethanol was observed, which may be the result of tolerance developed towards the inhibitory effect of zolpidem. However, in chronically ethanol-treated rats, the multiple zolpidem treatment led to prolongation of ethanol-induced sleep similar to the values observed in non-zolpidem-treated control animals. This suggests that zolpidem multiple administration may inhibit tolerance towards ethanol in chronically ethanol-treated rats. In the experiment with zolpidem, there were effects on performance in a memory test and the impairment of passive avoidance task after multiple drug treatment when compared to the effects after single administration in control rats. In contrast, in chronically ethanol-treated rats, amplification of latency (especially after 2.0 mg/kg) was observed. The possible relationship between ethanol-induced sedation and latency values would be consistent with a higher contribution of the inhibitory effect of zolpidem, than a direct influence on memory processes in chronically ethanol-treated rats.


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P. Mikolajczak, I. Okulicz-Kozaryn, M. Nowaczyk, and E. Kaminska
Ethanol facilitation of short-term memory in adult rats with a disturbed circadian cycle
Alcohol Alcohol., July 1, 2001; 36(4): 292 - 297.
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