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Alcohol and Alcoholism Vol. 34, No. 3, pp. 349-354, 1999
© 1999 Medical Council on Alcoholism

PLATELET AND ERYTHROCYTE MEMBRANE FLUIDITY CHANGES IN ALCOHOL-DEPENDENT PATIENTS UNDERGOING ACUTE WITHDRAWAL

Paul Thompson*

Department of Psychiatry, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK

Received 24 April 1998; first review notified 9 November 1998; accepted 8 December 1998

This study tested the hypothesis that membrane fluidity may alter during the alcohol-withdrawal syndrome. Platelet membranes of alcohol-dependent patients (n = 7) were significantly more rigid than controls (n = 7) at the start of alcohol withdrawal (mean fluorescence anisotropy 203.1 x 10–3 vs 195.5 x 10–3 respectively, P = 0.03), but were significantly more fluid when withdrawal was complete (191.4 x 10–3 vs 199.2 x 10–3, P = 0.03). Consequently platelet membranes of patients adapted to the known acute fluidizing effect of alcohol by becoming more rigid, but underwent a marked fluidization during withdrawal. There were no significant changes in erythrocyte membrane fluidity during withdrawal.


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