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Alcohol and Alcoholism, Vol 34, 43-47, Copyright © 1999 by Medical Council on Alcoholism

ARTICLES

Involvement of nicotinic acetylcholine receptors in the regulation of alcohol drinking in Wistar rats

W Dyr, E Koros, P Bienkowski and W Kostowski
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Al. Sobieskieg 1/9, PL-02957 Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Warsaw Medical Academy, Warsaw, Poland; Corresponding author

The aim of the present study was to determine if nicotinic acetylcholine receptors (nAChRs) might be involved in the regulation of alcohol intake by Wistar rats. A non-selective nAChR agonist, nicotine, and a non-competitive nAChR antagonist, mecamylamine, were tested in alcohol-preferring Wistar rats maintained on a limited access (4 h/24 h) to ethanol (10%, v/v). In addition, the effects of nicotine and mecamylamine on intake of standard laboratory chow were studied in a separate control experiment. Nicotine (0.1-0.6 mg/kg, s.c.) decreased ethanol consumption, but had no effect on food intake. In contrast, mecamylamine (1-3 mg/kg, s.c.) did not alter ethanol drinking even at the dose (3 mg/kg) which significantly decreased food intake. These results suggest that activation of nAChRs may selectively reduce ethanol consumption in outbred Wistar rats.
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