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© 1998 Medical Council on Alcohol

other

SEMI-AUTOMATED CARBOHYDRATE-DEFICIENT TRANSFERRIN IN PRIMARY BILIARY CIRRHOSIS: A PILOT STUDY

PAMELA BEAN*, ASGEIR HUSA1, KARSTEN LIEGMANN2 and ERLING SUNDREHAGEN1

Millennium Strategies 418 N Westfield Road, Madison, WI 53717, USA
1Axis Biochemicals Grunerlokka, Oslo, Norway
2Specialty Laboratories. Inc. 2211 Michigan Avenue, Santa Monica, CA 90404. USA

*Author to whom correspondence should be addressed

Received 13 January 1998; first review notified 22 May 1998; accepted 20 June 1998

Primary biliary cirrhosis (PBC) is one of the few non-alcohol induced liver pathologies which causes false positive results in the evaluation of carbohydrate-deficient transferrin (CDT) for the diagnosis of alcohol misuse. This phenomenon has only been observed when using the CDTect assay (Pharmacia & Upjohn, Uppsala, Sweden). In this study, we evaluated CDT in female PBC patients (n = 14) by a new CDT procedure, the %CDT turbidimetric immunoassay (TIA, Axis Biochemicals, Oslo, Norway) using the isoelectric focusing/immunoblotting/laser densitometry (IEF/IB/LD, Specialty Laboratories, Santa Monica, CA, USA) procedure as the gold standard. One of the PBC patients tested CDT + by IEF/IB/LD (cut-off > 9 densitometry units, DU) and %CDT TIA (cut off > 6%): one patient tested at the cut-off point of the IEF/IB/LD and another one tested at the cut-off point of the %CDT TIA. Thus, unlike CDTect. the %CDT TIA is a procedure that produces few false positives in PBC.


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