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© 1998 Medical Council on Alcohol

other

LIMITATIONS IN THE USE OF {gamma}-GLUTAMYL TRANSFERASE ESTIMATIONS IN ALCOHOL-DEPENDENT SUBJECTS

AUDREY HILLMAN*, ROGER A. D. SYKES and ARCHIBALD A. McCONNELL

Alcohol Treatment Unit, Ravenscraig Hospital Inverkip Road, Greenock PA16 9HA, UK

*Author to whom correspondence should be addressed

Received 4 March 1998; first review notified 16 April 1998; accepted 24 April 1998

This paper studies a cohort of randomly selected attenders at a district alcohol treatment service and examines the relationship between clinical assessments and laboratory markers currently in use in the Unit. It measures in particular the rate of change of serial {gamma}-glutamyl transferase (GOT) during abstinence throughout an alcohol treatment programme in alcohol-dependent subjects. The results show that GOT is less often elevated in alcohol-dependent patients than was previously thought. Its predictive value changes little with respect to the age of the subject and length of drinking history. Measurement of GGT adds little to the diagnostic sensitivity of careful history taking. In the alcohol-dependent population, GOT estimation is of little value and a normal GOT does not exclude chronic alcohol dependence.


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