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© 1998 Medical Council on Alcohol

other

PRESENCE OF PLASMA ENDOTOXIN IS CORRELATED WITH TUMOUR NECROSIS FACTOR RECEPTOR LEVELS AND DISEASE ACTIVITY IN ALCOHOLIC CIRRHOSIS

CHRISTOPHER HANCK*, SIEGBERT ROSSOL, ULRICH BÖCKER, MEHMET TOKUS and MANFRED V. SINGER

Department of Internal Medicine IV (Gastroenterology), University Hospital of Heidelberg at Mannheim Theodor-Kutzer-Ufer 1, 68167 Mannheim, Germany

*Author to whom correspondence should be addressed

Received 16 June 1998; first review notified 17 August 1998; accepted 18 August 1998

Cytokines and plasma endotoxin were measured in a consecutive series of patients with alcoholic cirrhosis (AC). Endotoxaemia was found to be strongly correlated to increased plasma levels of functionally active tumour necrosis factor (TNF) receptors -p55 and -p75, TNF-{alpha}, and the Child-Pugh stage of the disease. Our data support the hypothesis of the pathogenic role of lipopolysaccharide in hepatocellular damage of patients with AC.


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