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© 1998 Medical Council on Alcohol

research-article

ADJUVANT TRAZODONE IN THE TREATMENT OF ALCOHOLISM: AN OPEN STUDY

L. JANIRI*, A. HADJICHRISTOS, A. BUONANNO, R. RAGO, P. MANNELLI and S. DE RISIO

Drug Addiction Unit, Institute of Psychiatry, Faculty of Medicine, Catholic University Rome, Italy

*Author to whom correspondence should be addressed at: Servizio Farmacodipendenze e Alcolismo, Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Roma, Italy

Received 25 September 1997; first review notified 21 January 1998; accepted 23 January 1998

Serotonergic drugs have been proven to be helpful to alcoholics in maintaining abstinence. In this open study, we report that the atypical antidepressant trazodone at low doses was able to significandy decrease craving for alcohol, depressive, and anxious symptoms in a number (25) of detoxified alcohol-dependent subjects after 3 months of treatment. Trazodone may, therefore, be an adjuvant in the therapy of alcoholism.


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