© 1998 Medical Council on Alcohol
research-article
A NEW ORAL LOW-CARBOHYDRATE ALCOHOL LIQUID DIET PRODUCING LIVER LESIONS: A PRELIMINARY ACCOUNT
National Public Health Institute, Alcohol Research Center POB 719, 00101 Helsinki, Finland
*Author to whom correspondence should be addressed
Received 9 December 1997; first review notified 9 February 1998; accepted 9 February 1998
Male Wistar rats were administered a modified, but nutritionally adequate, ethanol liquid diet with a low content of carbohydrate (5.5% of energy). The high daily intake of ethanol (mean 12.9 g/kg body wt) resulted in consistently sustained elevation of diurnal blood ethanol levels (mean 40.3 ± 14.9 mmol/l, corresponding to 180 mg/dl). Marked micro- and macrovesicular panlobular steatosis, occasional inflammatory foci and a threefold elevation of serum alanine aminotransferase activity developed in 6 weeks. In livers from rats on regular 11% carbohydrate diet, lesions beyond periportally located steatosis were race. These observations suggest that oral administration of a low-carbohydrate liquid ethanol diet may provide an affordable alternative to the technically demanding intragastric feeding model for experimental studies of alcoholic liver disease.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. N. Baumgardner, K. Shankar, S. Korourian, T. M. Badger, and M. J. J. Ronis Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G355 - G364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Sampey, B. J. Stewart, and D. R. Petersen Ethanol-induced Modulation of Hepatocellular Extracellular Signal-regulated Kinase-1/2 Activity via 4-Hydroxynonenal J. Biol. Chem., January 19, 2007; 282(3): 1925 - 1937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. BYKOV, M. PALMEN, L. PIIRAINEN, and K. O. LINDROS ORAL CHRONIC ETHANOL ADMINISTRATION TO RODENTS BY AGAR GEL DIET Alcohol Alcohol., November 1, 2004; 39(6): 499 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. J. Ronis, R. Hakkak, S. Korourian, E. Albano, S. Yoon, M. Ingelman-Sundberg, K. O. Lindros, and T. M. Badger Alcoholic Liver Disease in Rats Fed Ethanol as Part of Oral or Intragastric Low-Carbohydrate Liquid Diets Experimental Biology and Medicine, April 1, 2004; 229(4): 351 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. J. Ronis, S. Korourian, M. Zipperman, R. Hakkak, and T. M. Badger Dietary Saturated Fat Reduces Alcoholic Hepatotoxicity in Rats by Altering Fatty Acid Metabolism and Membrane Composition J. Nutr., April 1, 2004; 134(4): 904 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Bykov, H. Jarvelainen, and K. Lindros L-CARNITINE ALLEVIATES ALCOHOL-INDUCED LIVER DAMAGE IN RATS: ROLE OF TUMOUR NECROSIS FACTOR-ALPHA Alcohol Alcohol., September 1, 2003; 38(5): 400 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Hunter, C. Neagoe, H. A. Jarvelainen, C. R. Martin, K. O. Lindros, W. A. Linke, and V. R. Preedy Alcohol Affects the Skeletal Muscle Proteins, Titin and Nebulin in Male and Female Rats J. Nutr., April 1, 2003; 133(4): 1154 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Chakkalakal, J. R. Novak, E. D. Fritz, T. J. Mollner, D. L. McVicker, D. L. Lybarger, M. H. McGuire, and T. M. Donohue Jr CHRONIC ETHANOL CONSUMPTION RESULTS IN DEFICIENT BONE REPAIR IN RATS Alcohol Alcohol., January 1, 2002; 37(1): 13 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. J. Kerai, C. J. Waterfield, S. H. Kenyon, D. S. Asker, and J. A. Timbrell REVERSAL OF ETHANOL-INDUCED HEPATIC STEATOSIS AND LIPID PEROXIDATION BY TAURINE: A STUDY IN RATS Alcohol Alcohol., July 1, 1999; 34(4): 529 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Lukkari, H. A. Jarvelainen, T. Oinonen, E. Kettunen, and K. O. Lindros SHORT-TERM ETHANOL EXPOSURE INCREASES THE EXPRESSION OF KUPFFER CELL CD14 RECEPTOR AND LIPOPOLYSACCHARIDE BINDING PROTEIN IN RAT LIVER Alcohol Alcohol., May 1, 1999; 34(3): 311 - 319. [Abstract] [Full Text] [PDF]
|
|