© 1998 Medical Council on Alcohol
review-article
B VITAMIN DEFICIENCY AND NEUROPSYCHIATRIC SYNDROMES IN ALCOHOL MISUSE
Kent Institute of Medicine and Health Sciences, University of Kent at Canterbury Kent CT2 7NR, UK
1Link Pharmaceuticals Ltd Horsham, W. Sussex, UK
2Greenwich District Hospital London SE10, UK
*Author to whom correspondence should be addressed
Received 11 July 1997; in revised form 16 January 1998; Alcohol misuse and alcohol withdrawal are associated with a variety of neuropsychiatric syndromes, some of which are associated with significant morbidity and mortality B vitamin deficiency is known to contribute to the aetiology of a number of these syndromes, and B vitamin supplementation thus plays a significant part in prophylaxis and treatment. In particular, the Wernicke-Korsakoff syndrome (WKS), due to thiamine deficiency, is a common condition in association with alcohol misuse, and is associated with high morbidity and mortality. Nicotinamide deficiency may result in a rarer condition, alcoholic pellagra encephalopathy, which often has a similar clinical presentation to WKS. This review considers the role of B vitamins in the aetiology and treatment of neuropsychiatric syndromes associated with alcohol misuse, with particular emphasis on WKS.
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